NEONATAL
LUPUS ERYTHEMATOSUS. A CASE REPORT
Carbajal RL, Zarco RJ, Rodríguez
HR, Rodríguez JR, Reynés MJ, Barrios FR, Luna FM.
Pediatrics National Institute, México City, México.
Neonatal lupus
erythematosus (NLE) is defined as the presence of maternal transplacentally
transmitted IgG autoantibodies; fetal or neonatal lesions depicts clinical
characteristic data. Although the detection of those autoantibodies is
highly sensitive, they are not specific.
Case report. A 1 month
old female presented to a reference hospital with a history of a non
specific facial dermatitits in her mother; dermatological lesion in the
neck, which disseminated to the face, skull, trunk, and extremities were
noted in the patient during the first week of life. Skin lesion were
annular shaped, erythematous with whitish center; and with fine
desquamation; palatine and oral cavity ulcers were also found. Laboratory
investigation disclosed 45,000 platelets/mL, normal hepatic function tests
and EKG, and postive (++++) anti-Ro and anti-La antibodies. A perivascular
inflammatory infiltrate, in the papillary dermis and dermal interface
consistent with NLE were found in a skin biopsy. Systemic lupus
erythematosus (SLE) was searched and demonstrated in the mother of the
patient.
Conclusions. Our case presented with hematological
and dermal lesions but without cardiac blockage, nor hepatic involvement;
the diagnosis of SLE was performed in the mother of the patient once the
diagnosis of NLE was established. Neonatal, lupus
erythematous.