Lin Ruichun, Chen Shi, Fen Bin, Le Xing and Su Zhuowa

Nanshan People’s Hospital, Shenzhen (518052), China


Objective:  4 cases of 21 patient children with Kawasaki disease (KD) had been detected to be positive Rotavirus Antigen (RVAg) in their stool. This summary might lead to attention to the correlation between RV infection and the pathogenesis of KD.

Methods: Diagnosis of KD was based on the Diagnostic Standard of Kawasaki Research Committee rectified on Sept. 1984, Japan. RVAg in stool were detected with ELISA.

Results: (1) All of the 4 patient children had the first symptom of diarrhea in the prevalence season of RV. And their stool had been detected to be positive RVAg; (2)Of the 4 patient kids, there were 3 males and 1 female, Their ages were 2, 3, 5 and 6 months respectively;  (3)After 3-8 days of diarrhea respectively, all of the 4 cases had the typical manifestations of KD; (4) 3 of the 4 cases had the coronary damages in the course of 5, 11and 21days respectively; (5) Therapy with intraveueous immunoglobulin had the markedly effects in all of the 4 pactient children.

Conclusion: The pathogenesis of KD has been unknown up to now, infections might play an important role. Our summary about the KD with positive RVAg in stool is the first report in the world. It is suggested that RV infection may be related to the pathogenesis of KD. The possible role of RV enteritis in the break of KD remains to be identified.