KAWASAKI DISEASE WITH POSITIVE
ROTAVIRUS ANTIGEN IN STOOL
Lin Ruichun, Chen Shi,
Fen Bin, Le Xing and Su Zhuowa
Nanshan People’s
Hospital, Shenzhen (518052), China
Objective: 4 cases of 21 patient children with
Kawasaki disease (KD) had been detected to be positive Rotavirus Antigen
(RVAg) in their stool. This summary might lead to attention to the
correlation between RV infection and the pathogenesis of KD.
Methods: Diagnosis of KD was
based on the Diagnostic Standard of Kawasaki Research Committee rectified
on Sept. 1984, Japan. RVAg in stool were detected with ELISA.
Results: (1)
All of the 4 patient children had the first symptom of diarrhea in the
prevalence season of RV. And their stool had been detected to be positive
RVAg; (2)Of the 4 patient kids, there were 3 males and 1 female, Their ages
were 2, 3, 5 and 6 months respectively;
(3)After 3-8 days of diarrhea respectively, all of the 4 cases had
the typical manifestations of KD; (4) 3 of the 4 cases had the coronary
damages in the course of 5, 11and 21days respectively; (5) Therapy with
intraveueous immunoglobulin had the markedly effects in all of the 4
pactient children.
Conclusion: The pathogenesis of KD
has been unknown up to now, infections might play an important role. Our
summary about the KD with positive RVAg in stool is the first report in the
world. It is suggested that RV infection may be related to the pathogenesis
of KD. The possible role of RV enteritis in the break of KD remains to be
identified.