0395

THERAPEUTIC EFFECTS OF DEXAMETHASONE, AMINOGUANIDINE, AMRINONE ON ENDOTOXIC SHOCK

Tang Haoxun, Fang Xunmei

Beijing Children's hospital, Beijing, China

Objective: To compare the therapeutic effects of amrinone, aminoguanidine (AG) and dexamethasone (Dex) on endotoxic shock.

Method: Thirty-five New Zealand rabbits were randomly divided into five groups. Seven rabbits without using lipopolyssacharide (LPS) is control. Other groups were intavenously injected LPS (400ug/kg) in 10 min.When BP fell down 10%, three groups received AG (30mg/kg iv), amrinone (1mg/kg bolus, followed by 10ug/kg.min iv), Dex (1mg/kg iv) respectively. The last is LPS group.

Results: At 6hrs after injection of LPS, (1). BP, CO, oxygen dilivery (DO₂), oxygen consumption (VO₂) NO were kept on normal level in control. (2) Bp and CO of LPS group decreased to 47±4.4 mm Hg, 170±42.6 ml/ min; DO₂ and VO₂ declined to8.1±2.4and 2.7±1 ml/kg.min, NO increased to 160.2±17.5 umol/L. (3) Treatment of Dex significantly improved BP, CO to 72±58mmHg, 262±42.5ml/ min; DO₂ to 12.4±3.1; VO₂ to 5.1±1.6ml/kg.min, NO to 99.6umol/L (4)These indicators of amrinone were improved. Bp is 62.8±8.1mm Hg; CO,197.5±39.5 ml/min; DO₂ 9.5±1.3 ml/kg.min; VO₂ 4.1±1.5ml/kg.min, NO148.2±14umol/L. (5) BP is 74.3±9.9mmHg;CO is 247.9±46.9ml/min; DO₂ and VO₂ are 11.2±1.7 ml/kg.min,5±1 ml/kg.min, NO is 58.2±7.7umol/L in AG.

Conclusion: All the three drugs have theraputic effect on endotoxic shock, but aminoguanidine is more effective than Dex and amrinone.