Tang Haoxun, Fang Xunmei

Beijing Children's hospital, Beijing, China


Objective: To compare the therapeutic effects of amrinone, aminoguanidine (AG) and dexamethasone (Dex) on endotoxic shock.

Method: Thirty-five New Zealand rabbits were randomly divided into five groups. Seven rabbits without using lipopolyssacharide (LPS) is control. Other groups were intavenously injected LPS (400ug/kg) in 10 min.When BP fell down 10%, three groups received AG (30mg/kg iv), amrinone (1mg/kg bolus, followed by 10ug/kg.min iv), Dex (1mg/kg iv) respectively. The last is LPS group.

Results: At 6hrs after injection of LPS, (1). BP, CO, oxygen dilivery (DO2), oxygen consumption (VO2) NO were kept on normal level in control. (2) Bp and CO of LPS group decreased to 474.4 mm Hg, 17042.6 ml/ min; DO2 and VO2 declined to8.12.4and 2.71 ml/kg.min, NO increased to 160.217.5 umol/L. (3) Treatment of Dex significantly improved BP, CO to 7258mmHg, 26242.5ml/ min; DO2 to 12.43.1; VO2 to 5.11.6ml/kg.min, NO to 99.6umol/L (4)These indicators of amrinone were improved. Bp is 62.88.1mm Hg; CO,197.539.5 ml/min; DO2 9.51.3 ml/kg.min; VO2 4.11.5ml/kg.min, NO148.214umol/L. (5) BP is 74.39.9mmHg;CO is 247.946.9ml/min; DO2 and VO2 are 11.21.7 ml/kg.min,51 ml/kg.min, NO is 58.27.7umol/L in AG.

Conclusion: All the three drugs have theraputic effect on endotoxic shock, but aminoguanidine is more effective than Dex and amrinone.