SIGNIFICANCE
OF DETECTION OF CYTOKINES INF-g,
G-CSF ET AL IN THE CSF OF CHILDREN WITH CNSI IN THE DIFFERENTIAL DIAGNOSIS
Jin Yu, Xue Junli, Duan
Hongmei
The First Affiliated Hospital, Lanzhou Medical College, Gansu,
China
Objective: To investigate the diagnostic value of the
interferon gamma (INF-g), granulocyte colony
stimulating factor (G-CSF), tumour necrosisfactor-α (TNF-α), interleukin-6 (IL-6)
and interleukin-8 (IL-8) in the cerebrospinal fluid (CSF) from the children
with acute central nervoue system infection (CNSI) due to different
etiology.
Methods: The CSF concentrations
of INF-γ, G-CSF, TNF-α, IL-6 and IL-8 were
measured in 14 children with purulent meningitis (PM), 30 acute viral
meningitis (VM) and 28 aseptic meningitis (AM) children by emzyme linked
immunosorbent assay (ELISA).
Results: The CSF levels of G-CSF and IL-8 were
significantly higher in the PM group than in the VM and AM group. The INF-g levels was markedly
higher in the CSF of patients with VM and AM than in that of patients with
PM. The TNF-αand IL-6 levels were
obviously higher in the PM, VM and AM groups compared with the control
group. The levelsof G-CSF and IL-8
in the CSF was positively correlated with neutrophil count；The INF-g concentration was not
correlated with neutrophil count et al.
Conclusion: The CSF levels of G-CSF
and IL-8 may be helpful to distinguish PM from VM and AM. The INF-g may be valuable in
differential diagnosis between VN, AM and PM. The CSF levels variation of
TNF-αand IL-6 were no significance in the differential diagnosis for CNSI.