CHANGES OF
PREALBUMIN BETWEEN INTERMITTENT NASOGASTIC AND INTERMITTENT NASODUODENAL
FEEDINGS IN LOW BIRTH-WEIGHT INFANTS
Lu H, Xue XD, Zhang JX
Dept. of Pediatrics, The 2nd Clinical College of China Medical
University, Shenyang, China
Objective: To compare and evaluate the effects of
intermittent nasogastric feeding (INGF) with intermittent nasoduodenal
feedings (INDF) on nutrient intake, Changes of serum prealbumin,
feeding-related complications in low birth-weight infants (LBWIs).
Methods: 40 LBWIs (birth-weight from 1 050 g to 1 920 g)
were randomizedly assigned into
INGF or INDF and fed with the same milk formula. There was no significant
difference between the two groups in the components of gender, gestation,
and birth-weight（P＞0.05）. Recorded intake of
liquid (including intravenous and oral), caloric intake, protein intake,
stool characters, and feeding-related complications; Serum prealbumin (PA)
were detected by ELISA before
feeding and by the end of the first week of initial feeding.
Results:
Within a week after
feeding, milk input were 67.2±38.8 ml/ (kg·d), 55.7±36.6 ml/ (kg·d) respectively in INDF and INGF
groups; the caloric intake and the protein intake supplied by milk were
217.1±125.5 kJ/ (kg·d) vs 188.7±126.4 kJ/ (kg·d) and 1.62±0.9 g/ (kg·d) vs 1.22±0.82 g/ (kg·d); The nutrient intake in INDF was
significantly higher than that in INGF (P<
0.001). The time of reaching 418.4 kJ/ (kg·d) by enteral feeding were
respectively 9.3±1.9 d and 13.9±7.4 d , the birth-weight regain time
were 8.4±1.8 d vs 10.2±2.5 d , all these parameters in INDF were significantly less than those
in INGF (P<0.05). The blood
level of PA in INGF and INDF were 180.2±47.8 mg/L and 185.2±49.0
mg/L respectively （P> 0.05）; after a weekly feeding, they
increased to 196.9±58.4 mg/L and 245.0±71.7
mg/L（P<0.05）. Serum levels of PA were
significantly higher than in INGF (P<0.05). But there was no such
complication as diarrhea in the two groups. The morbidities of such complications
as apnea and pneumonia caused by aspiration, vomiting, gastric residue were
significantly less in INDF than those in INGF, but there was no significant
difference in statistics (P＞0.05); However, the morbidity of
hyper-bilirubinemia was significantly less in INDF than that in INGF (P＜0.01).
Conclusion nasoduodenal feedings is a better
tolerable way while initial feeding of low birth-weight infants than
nasogastric feeding.