0407

Diagnosis value spectral indexes of heart rate variability in children with beta-adrenergic receptor hypersensitivity

Yu G-S, Jiang DQ, Tian J, Zhong Z-J, Liu X-Y, Qian Y-R, Chen Y

Children’s Hospital of Chongqing, Chongqing, China

Objective: The aim of the study was to discuss the diagnosis value of autonomic nervous tone change in children with β-AR hypersensitivity by analysis spectral indexes of HRV.

Methods: Spectral indexes of HRV were measured in 23 children withβ-AR hypersensitivity, and 13 hyperthyroidism and 26 healthy control. Results: 1. Over a 24-hour period: In patients withβ-AR hypersensitivity and hyperthyroidism , there were significance increase both HF_UN% and LF/HF comparing with the control group. Whereas there were no significance changes comparing with β-AR hypersensitivity and hyperthyroidism. 2. In patients withβ-AR hypersensitivity and control group, there were significance increases in the indexes of LF_UN and LF/HF ratio during waking hours; whereas both HFUN and HF bands were significance increase during sleeping hour. In patients with hyperthyroidism, there were no significance differences in all spectral indexes of HRV Comparing with waking hours and sleeping hours. Conclusion: In children withβ-AR hypersensitivity respond differently to the catecholamine stimulus , and show sympathetic nervous activity increased relatively. But cardiac autonomic nervous activity still had a circadian rhythm, similar to normal subject. This is a important value in diagnosisβ-AR hypersensitivity by analysis of HRV.