HEART RATE VARIABILITY AND ITS RELATION TO ECT AND CK-MB IN CHILDREN WITH HEART DISEASE

Yang XM, Zheng XQ

Department of Pediatrics, Union Hospital, Wuhan, China

 

Objective: To investigate the changes of heart rate variability (HRV) of the children with heart disease and the relationship between HRV and ECT, CK-MB.

Methods: HRV time domain analysis method of Premier IV Holter system was used to study 22 children with congenital heart disease(CHD), 26 children with myocarditis, 25 children with suspect myocarditis, 26 children with arrhythmia and 27 age-matched healthy children. Ejection fraction (EF) was examined in CHD patients, and ECT, CK-MB was examined in myocarditis, suspect myocarditis and arrhythmia patients.

Results: (1) Five time-domain measures (SDNN, SDANN, SDNN Index, rMSSD, pNN50) were significantly decreased in children with CHD. But the level of reduction was not related to EF. (2) All HRV measures were significantly lower in myocarditis patients than the controls. (3) There was no significant difference between suspect myocarditis patients and the controls. (4) SDNN, SDANN and SDNN Index were lower in arrythmia group than the controls. (5) All the measures of HRV were reduced in ECT abnormal group. (6) Most of the measures of HRV (SDNN, SDANN, SDNN Index, rMSSD) were decreased in CK-MB abnormal group.

Conclusion: The function of cardic autonomic nervous system is decreased in children with heart disease. HRV indices are sensitive markers of heart disease. HRV, ECT and CK-MB can be used together to evaluate the myocardium impairment.

 
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