THE CLINICAL SIGNIFICANCE OF THYROID HORMONE IN CHILDREN OF NEPHROTIC SYNDROM

FENG B, BAI X-Z, ZHANG W-S, LI S-L

The First Medical College, Harbin Medical University, Harbin, China

 

Objective: To investigate the changes of thyroid hormone (TH) abnormalities in nephrotic syndrome (NS), the serum free tri-iodothyronine  (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) levels were used to estimate the thyroid function when there is some alteration in serum binding protein of NS. 

Methods: Examined the serum FT3, FT4 and TSH of children of NS (n=30) were compared with control groups, who were age-matched children (n=20).

Results: In control groups, a significant decrease in FT3, FT4 (P<0.05) and increase in the serum TSH concentration (p<0.05) in NS were observed. We found that there was no relationship of the serum albumin or urinary protein with the serum FT3, FT4 and TSH in NS.

Conclusion: The thyroid function have a significant decrease in children of NS, so we may use the FT3 and FT4 level to judge the severity of NS, observe the therapeutic efficacy and predict the prognosis.

 

 
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