LEVELS OF CORD SERUM LEPTIN:
RELATIONS TO BIRTH WEIGHT AND RELATIONS TO INSULIN AND CORTISOL
Zhang W-S, Bai X-Z, Mi Y, Li S-L
The First Medical College of Harbin Medical University,
China
Objective: To determine the relationships
between cord serum leptin levels and birth weights, and to investigate the
relationships of leptin, insulin and cortisol.
Methods: Fifty-six
normal newborns were studied, male 32 cases, female 24 cases. These
newborns’ mean fetal age was 38.95±0.90 weeks and birth weight was
3.83±1.32kg. Cord blood was taken at delivery .The concentrations of cord
serum leptin, insulin and cortisol were measured by radio-immunoassay.
Results: The average concentrations of leptin were
6.35±3.07µg/L, significantly correlated with birth weight (r=0.69,
p<0.05), body mass index (BMI, r=0.35, p<0.05), chest circumference
(r=0.42, p<0.005) and upper extremital circumference (r=0.43,
p<0.005), but have no gender difference and no relation with maternal
BMI. Cord leptin levels were negatively correlated with cortisol
(32.75±16.63ng/ml, r =-0.33, p<0.05), but have no relation to insulin
(124.15±57.54 µIU/ml).
Conclusion: Cord serum
leptin levels were positively correlated with birth weight, BMI, chest
circumference and upper extremital circumference of the newborns and
negatively related with the levels of cortisol, but have no relation to
insulin.