0426

PECULIARITY OF COURSE OF BRONCHIAL ASTHMA IN CHILDREN LIVING IN THE ARAL SEA REGION

Imambaeva T, Mazhitova Z, Samuratova R, Peretyatko N

Kazakh State Medical University, Almaty, Kazakhstan

Objective: Severe ecological conditions which are in Kazakhstan, were served of basis for mean this region as ufavourable ecological zone – Aral Sea Region (ASR). Violation of ecological balance and visible health aggravation of population were started observe from 1970.

Methods: An analysis of the clinic course of the BA was being held in this work. In all 58 patients of age from 1 to 14 y.o. were being under the observation. It’s high percentage of early age children (41,4%).

Results: A sensibilization to allergens of home dust(56%), to pollens (16%), to food allergens(14%), to medicine(8%), to animals’ hair and dandruff(6%) is triggers of BA. A polyvalent sensibilization was being revealed at most of the children(51%).Infectious antigens are triggers in 17,2% cases. Absolute prevalence of heavy and middle heavy forms (it’s 51,72% and 48,27% accordingly). Analysis of the immunologyc indexes was revealed direct dependence between flow difficulty and IgE, T- and B-lymphocytes level. The indexes of IgE - 689,7+67,1 (by heavy course), 512+69,4 (by middle heavy course); Т-lymphocytes-suppressors 47,28+1,76 and 49,91+0,58; В-lymphocytes 21,62+0,54 and 24,35+0,5 accordingly were being marked in the children.

Conclusion: Expressed lowering of T-suppressors in direct dependence from process’s difficulty was being marked. Considerable oppression of cellular immunity is mark in BA at the children living in ASR.