THE CLINICAL STUDY OF
SYSTEMATIC INFLAMMATORY RESPONSE SYNDROME AND MULTIPLE ORGAN DYSFUNCTION
SYNDROME
Wang
SZ, Gao WW, Zhao DC
Maternal and Child
Health Hospital of Guangdong Province, Guangzhou, China
Objective: We approach
the different period of serum complement activity, platelet count and the
concentration of C-reactive protein (CRP) in patients with SIRS, and to
predict the clinical value of MODS led by persistent SIRS.
Methods: A
prospective controlled trial was carried out in 84 patients with SIRS (as
the study group). Before and after therapy, we used immunoassay
turbidimetry quantitive analysis to detect the activity of C3 C4
and dynamic study the CRP concentration. Meanwhile, the platelet count and
its dynamic changing was estimated by an automatic blood cell counter. 80
patients without SIRS were admitted to the control group. According to the
treatment response, the study group was divided to group A (SIRS persisted≤3 days);
Group B (SIRS persisted≥3 days). A crosscheck analysis was carried out
among the group A, Group B and the control group.
Results: Before
therapy, the activity of C3 C4, CRP concentration and
platelet count in patients with SIRS were all higher than that in the
control group (P<0.001). By series study, we knew that all of the index
were lower in group A (SIRS persisted≤3 days) after therapy
(P<0.01). We compared group A and control group, there were no
difference (P>0.05). In group B (SIRS persisted≥3 days), the
activity of C3 C4, platelet count were persistently
decreased but CRP concentration persistently increased. There was
significant difference between group B and control group (P<0.05).
Compare to group A and control group, the MODS morbidity was much higher (t
value were 5.69,4.37 P<0.05).
Conclusion: The patients with SIRS persisted≥3 days, their
activity of C3 C4 and platelet count were
persistently decreased but CRP concentration persistently increased. It is
probably a signal that the disease has attacked the vitals in patients with
SIRS. We could provide theoretic basis for predicting the occurrence of
MODS. It is an important mechanism to infer the activity of complement in
SIRS deterioration exacerbation.