THE CLINICAL EFFICIENCY
OF CTX IMPULSE THERAPY ON REFRACTORY NEPHROTIC SYNDROME AND INFLUENCE ON
SERUM SOLUBLE IN TERLEUKIN-2 RECEPTOR INPATIENTS
Cao L, Zhang JL, Chen DK
Capital Institute of
Pediatrics, Beijing, China
Objective: To evaluate
the clinical efficiency of CTX impulse therapy on refractory nephrotic
syndrome and on the serum level of soluble interleukin-2 receptors.
Methods: 15 cases of
refractory nephrotic syndrome at active stage were treated with CTX, 8~12
mg/kg/time i.v. on two consecutive days once two weeks for 4~6 times. The
cumulative doses were 60~120 mg/kg. The serum levels of soluble sIL-2R were
detected before and after treatment using ELASA.
Results: The complete
and total remission rate was 73.3%(11/15) and 80.0%(12/15), respectively.
Among 9 cases steroid -resistant, 5 cases revealed complete remission to be
a complete remission rate 55.6%, 1 casereached partial remission, the total
remission rate was 66.7%. Of 10cases in remission, 7 cases were in their
continuous complete remission (3 cases>2 years, 2 cases>1 year, 1
case>half a year). The sIL-2R level in serum decreased after treatment.
Conclusion: CTX impulse
therapy can achieve favorable therapeutic results for refractory syndrome
andserum sIL-2R is a sensitive indicator of evaluating efficiency.