THE STUDY ON THE LEVERS OF T-LYMPHOCYTIC CLUSTER
OF DIFFERENTIATIONS IN NEONATES WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY
Lin NY, Fang XY, Wu BY, Xu LD, Li T, and Guo JZ
The First Affiliated Hospital of Shantou
University Medical College, Shantou, China
Objective: To study the changes of
cellular immunity function in neonates with hypoxic-ischemic encephalopathy
(HIE) by determining the levers of T-lymphocytic cluster of
differentiations.
Methods: The CD3+,CD4+,CD8+,and
CD4+/CD8+ levers in 30 HIE neonates during acute period and recovery period
and 15 normal neonates were measured by means of double-immunofluorescence
direct labeled assay through flow cytometry.
Results: (1) The CD3+ and CD4+
levers in HIE neonates during acute period were 25.22±15.15(%) and
15.70±10.79(%), which were lower than those in normal ones which were
42.25±8.22(%) and 33.84±5.57(%). The differences between them were
significant in statistics (P<0.05, P<0.01). The CD8+ and CD4+/CD8+
levers in HIE neonates during acute period were lower than those in normal
ones but the differences were not significant(P>0.05, P>0.05). (2)
The CD3+ and CD4+ levers in HIE neonates during recovery period were
46.89±16.43(%) and 27.17±5.86(%), which were higher than those during acute
period. The differences between them were significant in statistics
(P<0.05, P<0.01). The CD8+ and CD4+/CD8+ levers in HIE neonates
during recovery period were higher than those during acute period. But the
differences were not significant (P>0.05, P>0.05). (3) Compared the
levers of CD3+,CD4+,CD8+, and CD4+/CD8+ between HIE neonates during
recovery period and normal neonates, there were no significant
difference(P>0.05).
Conclusion: The cellular immunity function in HIE neonates was decreased
and could recover after therapy.