AN EIGHT-YEAR REVIEW OF MULTIPLE DRUG THERAPY FOR
SEVERE APLASTIC ANEMIA IN CHILDREN
Yu Suming, Guo
Guirong, Xie Jianjun, Sun Jing
Pediatrics,
304th Hospital, Beijing 100037, China
Objective: To review and evaluate multiple therapy for severe aplastic
anemia (SAA) in pediatric patients at our hospital for the past eight
years.
Methods:
A total of 32 children with SAA were divided
into three groups and treated over three months. Treatment regiment for
each group were as follows: Group A: 9 patients were treated using
Stanozolol and suspend liquid of fetal liver; Group B:10patients were
treated using Cyclosporin(CSA) and stanozololum; Group C:13 patients were
treated using Granulocyte-stimulating-factor(G-CSF),intravenous gamma
globulin (IVIG) and CSA. Each group was evaluated on complete peripheral
blood and bone marrow exam.
Results: No
significant response was observed in group A. In group B, compared to
values prior to therapy, the observed response was significant increase in
myelogenic erythocyte system count and decrease in lymphocytic count after
3 moths of treatment (P<0.05). In group C, 9 out of 13 patients had
significant hematologic recovery of bone marrow and peripheral blood in
comparison to values prior to therapy and to other treatment groups.
Furthermore, the patients in group C needed less blood.
Conclusions: Combined treatment with Stanozolol,CSA,IVIG and G-CSF produced
complete remission in majority of our patients with SAA, there was also
improved quality of life in majority of patients treated with all above
drugs compared to the other treatment groups.