THE RETROSPECTIVE ANALYSIS
OF CAUSE IN 2908 NEONATAL JAUNDICE
Yang Chuanzhong, Xiao Lijun
Shenzhen Women and Children’s Hospital,
Shenzhen, China
Objective: To study the cause of
neonatal jaundice in recent ten years.
Method: The cause of 2908 patients
with neonatal jaundice in this hospital during the past 10 years was
reviewed. In addition, the genetic predisposition of erythrocyte
glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborn infant was
studied.
Results: There are 2908 newborn
infants with jaundice (31.2%) in all 9337 admission neonate in our hospital
during the past 10 years. The patients with neonatal hyperbilirubinemia and
bilirubin encephalopathy among all neonate jaundice hold 95.2% and 1.4%
individually. The first three important diseases that result in neonatal
jaundice is: neonatal G6PD deficiency; pneumonia of newborn and hemolytic
disease of the newborn due to A and B incompatibility, holding 31.3%; 16.8%
and 14.1% for all neonatal jaundice. Especially, there are 0.5% and 0.1% of
newborn infants with jaundice that result from α- and β-
thalassemia. In addition, 66.7% newborn infants with erythrocyte G6PD
deficiency are boys and 33.3% girls. A wide investigation to their parents
shows: there are 35.6% of infant’s mother who have erythrocyte enzyme
deficiency, 17.8% of their father and both of their parents with this
deficiency hold 13.8%.
Conclusion: Although Shenzhen is an
immigrant city, the incidence of neonatal jaundice is significant high. We
suggest that erythrocyte G6PD deficiency of newborn infant were an
important disease that induces to neonatal jaundice in this area. Infection
and hemolytic disease of the newborn due to blood type incompatibility were
another main reason. Investigation show that erythrocyte G6PD deficiency of
newborn infant fit to incomplete sex linked dominant hereditary disorder.