STUDY OF SERUM LEPTIN CONCENTRATIONS IN NEWBORNS OF DIABETIC AND NON DIABETIC MOTHERS

EL Meneza .S, El Zayat1.T and Aly.Kh.N2

1Pediatrics And 2clinical Pathology Departements AL-Zahraa Univrsity Hospital Cairo, Egypt

 

Obiective: To measure serum leptin in newborns at birth and correlate it with (birth wight, length, head cicumferance and gestational age) and its relation to maternal diabetes mellitus.

Methods: This study was carried on 38 newborns: 18 infants of non diabetic mothers: 7(AGA), 11(LGA) and 20 infants of diabetic mothers : 11 (LGA), 9(SGA).all studied groups subjected to history taking, through clinical examination, anthropometric measurements (wt, L, HC).blood samples taken from umblical cord at birth for estimation of serum leptin, cholestrol, triglycerides and insulin.

Results: Showed that leptin values correlate positevly with birth weight, length, head circumferance and gestational age for newborns of both diabetic and non diabetic mothers and no significant difference between serum leptin either in newborns of both diabetic and non diabetic mothers (LGA). There is a postive correlation between leptin & cholesterol, triglycrides and insulin i.e: leptin increases with the increase in cholesterol, triglycrides and insulin.

Conculsion: leptin secretion probably occurs in utero, the strong postive correlation between birth weight and leptin concentration at term regardless of the presence or absence of diabetis suggests that adipose tissue mass is a majior determinent of leptin secretion in utero.

 
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