The significance of creatinine clearance rate with cimetidine
Sun LZ，Mo Y, Chen S-M, Yue ZH.
Department of Pediatrics,
The
First Affiliated Hospital of Sun Yat-Sen University of Medical Sciences,
Guangzhou, China
Objective: To detect
the significance of creatinine clearance rate (Ccr) with cimetidine in
children with glomerular diseases.
Methods: 53 children
with glomerular disease divided into 2 groups: Group A (Ccr ³ 80 ml/min/1.73m2) had 28 children, group B (Ccr < 80 ml/min/1.73m2) had 25 children. In the
experimental day, urine from 7Am to 9Am and urine from 10Am to 12N were
collected, and the urine creatinine was detected respectively. At 9Am on
that day, Cimetidine (0.8g/m2) was given to the experimental
children, and blood was taken for detection of serum creatininea at that
time. 2 hours Ccr of 7Am to 9Am (Ccr1) and 10Am to 12N (Ccr2) were
calculated respectively.
Results: Ccr2 was
significantly less than Ccr1 in both groups. In group A, the mean of
(Ccr1-Ccr2) was 5.51 ml/min, only 3.9% of the mean of Ccr2. But in group B,
the mean of (Ccr1-Ccr2) was 55.36 ml/min, 103.4% of the mean of Ccr2.
Regression analysis show a significant negative relationship between
(Ccr1-Ccr2)/Ccr2 and Ccr2, r =
-0.791，P< 0.05.
Conclusion: It is
better to use Ccr with cimetidine to assessing renal fuction in children
with glomerular diseases when their Ccr were less than 80 ml/min/1.73m2.