RELATIONSHIP
OF NEONATAL SERUM ZINC CONCENTRATION AND DISTRIBUTION OF T-CELL SUBSPECIES
Yang MJ, Shen YH
International Maternity and Child Health
Hospital,
China Welfare Institute, Shanghai 200030 China
Objective: This study attempted to
define the relationship of neonatal serum zinc concentration and
distribution of T-cell subspecies.
Method: 47 preterm and 20 term
babies were enrolled and divided into 3 groups according to their
gastational age (GA) Group I: GA at 28-32 weeks, Group II: GA at 33-36
weeks and Group III include all of the term neonates that GA at 37-41
weeks. The blood sample was gotten after born and before eating milk. Serum
zinc concentration was measured by atomic absorption methods, and T-cell
subspecies by flowing cytometry.
Result: Serum zinc
concentration of Group I (77±24ug/dl) is
significantly lower than that of Group II (94±27ug/dl,p<0.05),and
Group III(94±16ug/dl,p<0.05),the incidence of low zinc
concentration was 35%. Rate of T-cell subspecies CD4+/CD8+ ratio of group
I(1.45±0.53) was significantly lower than that of group
II(1.78±0.47,p<0.05) and Group III(1.99±0.99,P<0.05);
Lymphocite and T-cell account of Group I (4.61±1.80×109 /L;2.81±1.23×109 /L,)
and GroupII(5.05±1.68×109 /L;2.95±1.34×109 /L)were
significantly lower than that of Group III(6.00±1.36×109 /L,3.8±0.93×109 /L,p<0.05),
CD4+T-cell level of 12 low zinc concentration cases(33.51±8.78%)lower
than normal neonate Group(40.03±11.09%,p<0.05),and
CD8+T-cell level (28.9±6.93%)was higher than that of normal baby Group(23.22±7.70%,p<0.05),the
rate of CD4+/CD8+ decreased apparently(1.22±0.37) and lower
significantly than that of normal Group(1.86±0.72,p<0.001)
Conclusion: There is a good relationship
between serum zinc concentration and GA, the smaller the GA, the lower of
the serum zinc concentration, the higher the incidence of low serum zinc
concentration. On the other hand, there is also a good relationship between
distribution of T-cell subspecies and GA and the serum zinc concentration. Suggestion was
made that serum zinc concentration of preterm babies should be monitored
especially smaller than 32 weeks.
Key word:
Neonate serum zinc concentration T-cell distribution