ATP STRESS ECHOCARDIOGRAPHY FOR DETECTION OF MYOCARDIAL SYSTOLIC
DYSFUNCTION IN CHILDREN WITH KAWASAKI DISEASE
XIA B, QIU
B-M, LIN ZH, LI CH-R.
ShenZhen
Children’s Hospital, ShenZhen China
Objective: The study was designed to assess the
feasibility and diagnostic significance of ATP stress echocardiography for
detection of myocardial systolic dysfunction in children with Kawasaki
disease.
Methods: ATP stress echocardiography
(160μg·Kg-1·min-1by 6min) was performed in
27patients of Kawasaki disease and 15normal children. Left ventricular EF,
FS and MRVs (Vs of mitral ring long axis) were measured by M-mode and
Tissue Doppler echocardiography respectively at rest and during the last
one minute of infusion of ATP, calculating the increased rate of EF, FS and
MRVs.
Results: during ATP stress, HR and
RPP were significantly increased (P<0.01)
and There were not serious complications. At rest, EF,FS and MRVs were
normal in every groups. During ATP stress, MRVs in patients were lower
significantly than in control group (P
<0.05). The increased rate of FS and MRVs were reduced in patients
compared with normal group (P<0.01,
P<0.05, respectively).
Conclusions: There was
myocardial systolic dysfunction in children with Kawasaki disease,
especially in left ventricular long-axis systolic dysfunction. ATP stress
echocardiography is a safe and effective diagnostic method for detection of
myocardial systolic dysfunction in Kawasaki disease, may be useful in
monitoring patients considered normal by echocardiography, and be suitable
for patients unable to do exercise test.