DETECTION OF HUMAN PARVOVIRUSB19
INFECTION IN CHILDHOOD HEMATOLOGICAL DISEASES
Li J1, Chen Z1, Cai XR1,
Wu XQ2, Jiang JH1, Guo RG1
1
Union Hospital Affiliated Fujian Medical University, Fuzhou, China
2
Fujian Medical University, Fuzhou, China
Objective: To observe the status with human parvoviousB19 (HPVB19)
infection in childhood hematological diseases, and explore the relation
with the diseases to HPVB19 infection.
Method:
The serum sample of 102 patients and 22 health children used as the control
group were tested for HPVB19-IgM and IgG by indirect ELISA.
Results:
The positive rate in the patients with idopathic thrombocytopenia (ITP) and
anaphylactoid purpura (AP) were separately 52.2% (12/23) and 65% (13/20),
markedly higher than that in the control group (2/22, 9.1%) (p<0.01).
The positive rate were 31.4% (11/35) of the patients with acute leukemia,
and 33.3% (4/12) of the patients with aplastic anemia, no significant
difference as compared with the control group (p>0.05). The positive samples
were found in 2 of 5 cases of myelodysplastic syndrome, 2 of 5 cases of
lyphoma, and 1of 2 cases of malignant histicytosis. The total positive rate
of the patients was 44.1% (45/102), higher than that of the control group
(p<0.01).
Conclusion: HPVB19 infection is main virus pathogen to childhood
hematological diseases, particularly to ITP and AP.