Detection of cytomegalovirus antigen in urine and
nephric tissue by immunohistochemistry and its clinical significance in
children with hematuria
Luan J-W, Wu Y-X, Xiong S-Y, et al.
Children¡¯s Hospital
of Wuhan, Wuhan, China
Objective: To investigate
the infection of cytomegalovirus in children with hematuria.
Method: Urine of 55
infants with hematuria were used to detect cytomegaiovirus early antigen
(CMVEA) by immunohistochemistry
(streptavidin-peroxidase or S-P method). Six of these infants received
renal biopsy and were detected
CMVEA in their nephric tissue.
Result: The positive
rate of CMVEA in children with asymptomatic hematuria was 80% (32/40),while
the positive of CMVEA in nephritis group and control group were 20% (3/15)
and 18.9% (10/53).The study showed that the positive rate of CMVEA in group
of asymptomatic hematuria was markedly higher than in group of nephritis
and control(p<0.005,p<0.05)Five of six children who received the
renal biopsy were detected the CMVEA in their nephric tissue,the positive
rate was 83%(5/6).Most of CMVEA in renal tissue were founded in the cells
of cortical collecting tubule.
Conclusion:
The primary pathogeny of asymptomatic hematuria likely is the
infection of cotymegalovirus.The nephrosis induced by infection of CMV is
commonly not serious: the swell and vacuolization of tubule were seen,
while the pathological changes of glomerul and interstitium are
inconspicuous.