THE ROLE OF BETA-3 ADRENERGIC RECEPTOR
TRP64ARG MUTATION IN CHILDREN'S SIMPLE OBESITY IN CHINA
Mo BQ, Chen
RH, Guo XR, Li XL, Gong HX, Pan XQ
Nanjing Medical
University, Nanjing, China
Objective: To
observe the role of beta 3-adrenergic receptor (beta-3 AR) Trp64Arg
mutation in children’s simple obesity
Methods: The beta-3 AR Trp64Arg mutation of 177children
were detected with the method of restricted fragment length polymorphism,
their body weight, height, circumstance in waist and hip, skin fold in subscapular, biceps and abdomen regions were
measured, BMI calculated. Their food consumption, living and eating habits
were investigated.
Results: There was beta- 3 AR Trp64Arg mutation among the
children, especially in obese girls. The BMI, waist to hip ratio, skin fold
in subscapular, biceps and abdomen regions were higher in obese children with or without
the mutation. No significant difference in food intake was observed between
the obese and non-obese children with the mutation, which was obvious between
obese and non-obese children without the mutation. The obese children with
the mutation were less active and did less exercises than non-obese
children with the mutation, which was not observed between the obese and
non-obese children without the mutation.
Conclusion: The results indicate that beta 3-AR Trp64Arg
mutation may play a role in children’s simple obesity in china.