THE RELATIONSHIPS BETWEEN LIPOPROTEIN LIPASE GENE POLYMORPHISMS
AND CHILDREN SIMPLE OBESITY
Guo X-R, Chen R-H, Mo B-Q,
et al.
Nanjing Medical University, Nanjing,.China
Objective:
To explore the relationships between two common DNA polymorphisms (Hind
III and Pvu II) at lipoprotein lipase (LPL) gene and children simple
obesity.
Methods:
PCR-RFLP was used to detect both Hind III and Pvu II polymorphisms in 92
simple obesity children and 80 healthy controls. The levels of plasma lipid
and lipoprotein, BMI, blood pressure, some physical indexes were also
measured.
Results:
(1) The genotype H+H+ frequency and the H+ allelic frequency in
obesity children were significantly higher than those in control group.
There were no significant differences in the distribution of both genotype
frequency and allelic frequency at LPL-Pvu II locus between these two
groups. (2) The polymorphisms of Pvu II and Hind III were in strong linkage
disequilibriums. Healthy children had a higher H+P- haplotype frequency
than obesity children did. (3) The levels of TG, TC, LDL-C, Apo B, BMI were
significantly higher and the level of Apo A/B was significantly lower in
obesity group with H+H+ genotype than those in obesity with H+H- genotype.
Conclusion: (1) Allele H+ may be a genetic susceptible
factor and P-H- haplotype may be a protective factor in the development of
children simple obesity. (2) LPL-Hind III polymorphism may modify the
levels of plasma lipid, plasma lipoproteins and BMI in children with simple
obesity. LPL-Pvu II polymorphism may not play a key role in the development
of children simple obesity.