The study on predonisone in
preventing renal involvement of children with Henoch-Schonlein purpura
Chen R-H, Huang W-Y, Huang S-M, Ding G-X
Nanjing Medical University, Nanjing, China
Objective: To investigate the effect of predonisone in preventing renal
involvement of children with Henoch-Schonlein purpura (HSP).
Methods: During December 1996 to
January 2000, 84 cases of children with HSP whose renal hadn’t been
involved were divided into two groups randomly, preventing group (44 cases)
which accepted predonisone treatment (1mg/kg.d) for 2 weeks and control
group(40 cases) which didn’t receive predonisone treatment. These patients
were followed up 1.6±0.7 years.
Results: (1) in control group,
14(35%) of 40 patients developed renal involvement; whereas only 4(13.6%)
of 44 patients who accepted predonisone developed HSPN (P<0.05). In HSPN
patients of both groups, the 24 hours excretion of protein in urine of
control group were very higher than that of preventing group (589.47±148.39mg/d versus 356.28±102.35mg/d respectively,
P<0.01). (2) This study also showed that the use of predonisone gave the
patients with HSP early could alleviate their abdominal and joint symptoms
positively (P<0.05), but it was no effects in preventing these symptoms
(P>0.05).
Conclusion: corticosteroids
such as predonisone can prevent renal involvement of children with
Henoch-Schonlein purpura early.