DEVELOPMENT OF CORPUS CALLOSUM IN THE CHILDREN
WITH DEVELOPMENT DELAY AND BRAIN INJURIES
Mao J1, Hashimoto K2,
Fujita T2, Hirayama T2
1 Dept. of Pediatrics,
Second of Hospital of China Medical University, Shenyang, China
2 Dept. of Pediatrics, Nippon Medical School
Second Hospital, Japan
Objective: To elucidate the
growth pattern of corpus callosum and the relationship between callosal
morphological changes and different pathological states of brain.
Methods: The different
thickness and diameter of corpus callosum were measured on the midline
saggittal section of T1 weighted imaging on
the intensity of 0.5Tesla. from the 126 normal ones, 36 patients with
development delay(DD), 12 patients with delay myelination or/and widen
extra cerebral space(DW), 21 patients with perinatal brain injury(BI).
Results: It has been shown that the corpus callosum grew in
logarithmic pattern, with an apparent growth spurt between birth and 2
years of life. The patients with DD, DW, and BI showed remarkable atrophy
of corpus callosum described by the thickness of genu, midbody and
splenium, and the ratios of their thickness to length of corpus callosum.
The most atrophy of corpus callosum has been shown in the group with BI,
even if compared with the group of DD, and DW. The thickness of genu and
its ratio to the length of corpus callosum were sensitive indicators for
the differences above. DW was the main causes of DD. The group for DD,
which excluded the eleven patients with delayed myelination or/and, widen
extra cerebral space also appeared hypoplastic corpus callosum, while
comparing with the normal group. Therefore, the delayed development or
hypoplasia of corpus callosum could characterize the patients with DD. In
addition, the location of callosal atrophy related to the region of the
injured white matter, with the most sever atrophy in the severe injured
brain.
Conclusion:
Aberrant development of corpus
callosum could indicate the states of brain development and injuries.