EARLIER DIAGNOSIS AND COMBINED THERAPY OF VIRAL
ENCEPHALITIS IN CHILDREN
Yu Y 1
1 Nanjing
Children's Hospital, Nanjing, China
Objective: To
investigate earlier diagnosis and combined therapy of viral encephalitis in
children.
Methods: Routine
and biochemistry and cell morphology of cerebrospinal fluid of 96 cases
withviral encephalitis in children were determined The patients were examined with computer tomography (CT) and
Electroencephalogram (EEG). Viral antibodies (IgG and IgM) of cerebrospinal
fluid of 51 cases were measured. 96 patients were treated with tracheal
cannula, continuous positive airway pressure (CPAP), phenobarbital, clonazepam,
diazepam, chloral hydrate, mannitol, furosemide, albumin and dexamethasone.
Results: Among the
96 patients, 54 were cured (56.25%), 31 improved, 9 auto-discharge (9.38%)
and 8 died (2.08%).
Conclusion: presence of EEG
abnormalities was earlier than routine, biochemistry, cell morphology of cerebrospinal
fluid and skull CT in viral encephalitis in children. Providing earlier
diagnosis. Very-high- dose phenobarbital for refractory status epilepticus
in children offered better results than diazepam. The therapy required
continuous electrocardiographic monitoring, support of circulation and
mechanical ventilation in PICU. Moderate and severe cerebral edema was
treated with mannitol.
Using differences of doses and dosing interval 4h. Decreasing dosage before
times. Courses were less than 1 week.