Pathological
Innervations Changes of Detrusor in Myelodysplastic Bladder and Its Clinical
Significance
Li W1, Chen Y-L2,
Li L1, Zhang J-Z1
1 Beijing Children’s Hospital,
Beijing, China
2 2nd Hospital
of Shandong University, Jinan,
China
Objective: To study the relationship between innervations
of detrusor and urodynamic classification in myelodysplastic bladder (MB).
Methods: 38 MB and
11 normal bladder specimens were obtained. MB specimens included detrusor
hyperreflexia 25 cases and detrusor hyporeflexia/areflexia 13 cases.
Immunohistochemical staining was performed using antibodies against S-100,
Neurofilament protein (NF200) and Synaptopysin (SY).
Results: (1)
Stronger staining of S-100 and NF200 was seen in detrusor hyperreflexia specimens,
compare with normal control (P<0.01 and P<0.05 respectively). 14 specimens
(56.0%) were also stained in smooth muscle bundle. The varicosities in
detrusor hyperreflexia were more abundant than those in control specimens (P<0.001).
(2) There was less staining of S-100 and NF200 in detrusor
hyporeflexia/areflexia specimens, compared with control (P<0.01 and P<0.05
respectively). 3 of them showed no staining of S-100 and NF200, clinical
urodynamic study manifested that there was no reflex of bladder detrusor.
The varicosities were significantly diminished in muscle bundle compare
with control (P<0.001). (3) There was no correlation of nerve density
between age and gender (P>0.05).
Conclusions: There is a
closed relationship between innervations of detrusor and urodynamic results
in MB. It is necessary to treat different type of MB with variety methods
respectively.