THE VALUE OF P300 IN JUDGING THE
COGNITIVE IMPAIRMENTS IN EPILEPTIC CHILDREN
Cai LY, Zhou MZ, Deng YZ, Xu SJ, Li WJ, Wang RL
Jiangxi Children’s Hospital, Nanchang, China
Objective: To study
the value of P300 of Event-related Potential (ERP) in judging the cognitive
impairments in epileptic children.
Methods: The
WISC-CR and P300 of ERP were used to assess the cognition in 106 epileptic
children and 40 normal children. P300 latency and amplitude evoked by
“oddball” stimulation were compared and analyzed with WISC-CR.
Results: P300
latency and amplitude in normal group were 346.78±23.22 and
13.68±6.44. There was an remarked difference in P300
latency between normal group and epilepsy group (P<0.01). But there was
no significant difference in P300 amplitude between them (P>0.05). The
analysis of linear correlation showed that the FIQ had a negative
correlation with the P300 latency (r=-0.57,P<0.01). FIQ and P300 latency
were no significant difference between before and after 6 months or 2.5
years treatment of patients with a routine dosage of PB and CBZ.However,the
abnormal rate of P300 in tonic-clonic seizures was 61.11%.
Conclusions: The
prolonged P300 latency may be taken as an objective index to judge the
cognition impairment in epileptic children. P300 test can avoid the
influence of education and dialects on WISC-CR.