THE
STUDY ON THE LEVELS OF EGF, NT, SS IN NEWBORNS WITH BIRTH ASPHYXIA AND RELATIVE ANALYSIS WITH
CLINICAL FACTORS
Mao ZQ, Sun M, Li J, Zhang H.
Pediatric Department of Second Clinical
Hospital, China Medical University, Shenyang, China
Objective To explore the affect of asphyxia on newborns’ gut hormones by the
levels of epidermal growth factor (EGF), Neurotensin (NT), Somatostatin
(SS) and relative analysis with clinical factors.
Method The
blood samples of were collected from 56 asphyxia patients and 39 normal
controls on the first day, 3rd day, 7th day after birth, the concentrations
of serum EGF and plasma NT, SS were assay successively with
radioimmunoassay method.
Results
The blood levels of NT, SS were higher significantly, and EGF was lower obviously
in asphyxia group than relative control groups (P<0.05); The
levels of EGF, SS turned to normal, while the concentrations of NT was
increased on seventh day in both mild and severe asphyxia when compared
with control group (116.4,118.2 vs 84.7, P<0.01); The relative
analysis of three hormone’s concentration with clinical factors suggested
that the EGF levels were positively correlated with the degree of asphyxia,
r=0.3149, P<0.01; but the NT was inverse, r=-0.368, P<0.001;
The levels of NT, EGF were positively correlated with gestation age and
milk intake respectively, P<0.01; The SS level was positively
correlated with FBS, r=0.222, P<0.05.
Conclusion The NT, SS levels were raised, the EGF was decreased
after birth asphyxia. They were relative with asphyxia degree. It was
suggested that this kind of abnormality of the gut hormones with perinatal
asphyxia were likely one of the causes of digestive function disorder.