A STUDY ON THE CHANGES OF NITRIC
OXIDE IN CEREBROSPINAL FLUID AND ITS CLINICAL SIGNIFICANT IN CHILDREN WITH
INTRACRANIAL INFECTION
Zhao Ping, Guo Xiudong, Yang Wenkang, Zhen Xiefei
The Department of Pediatrics, Hui Zhou People¡¯s
Central Hospital, Guangdong, China
Objective: To
investigate the relationship between the changes of nitric oxide in
cerebrospinal fluid and infections causes, degree of brain injury in
children with intracranial infection.
Methods: The
nitric oxide level of cerebrospinal fluid was determined by colorimetric
method in 15 cases with bacterial cerebritis, 27 cases with virus
cerebritis and 20 cases healthy children.
Results: The
nitric oxide levels of cercbrospinal fluid were obviously increased in the
intracranial infections group compared with the normal group,but no obvious
difference between bacterial and virus cerebritis. The nitric oxide levels
were obviously increased in the cases with high cerebrosoinal fluid
pressure and critical cerebral injury degree compared with the cases with
normal cerebrospinal fluid pressure and light cerebral injury degree. The
nitric oxide levels in cerebrospinal fluid also increased in the children
with virus cerebritis which conventional and biochemical determination of
cerebrospinal fluid was normal.
Conclusion: Nitric
oxide levels of cerebrospinal fluid increased obviously in the children
with intracranial infection compared with the healthy children, the
increasing degree of nitric oxide seemed to relate with the degree of the
brain injury, but has nothing to do with the infections causes. To
determine nitric oxide level of cerebrospinal fluid would help to diagnosis
the virus cerebritis which the conventional and biochemical determination.