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![文本框: EVALUATION OF ALBUMIN ADMINISTRATION IN JAUNDICED NEONATES WITH PHOTOTHERAPY
Nong S-H, Xie Y-M, Yu Y-H, Zhang Y-X, He S-R, Zhang Y-H, Sun Y-X
Department of Neonatal Medicine, Guangdong Provincial People’s Hospital, China
Objective: To evaluate albumin administration in jaundiced neonates with phototherapy.
Methods: Forty-eight neonates with jaundice were prospectively randomized into two groups: phototherapy + albumin administration (group PA) and phototherapy only (group PO). The inclusion criteria were: (1)Serum bilirubin levels within 205～340 µmol/L; (2)Gestational age of 37～42 weeks; (3)Phototherapy for the first time when admitted to NICU. The gestational age, birth weight, the age to put into phototherapy, red blood cells, hemoglobin, plasma albumin, and blood gas were all similar between two groups (p>0.05). All included neonates were put into phototherapy for 48 hours. Neonates of group PA were treated with phototherapy when albumin administration was finished. Neonates of group PO presented jaundice earlier than those of group PA [age (47.62 ± 15.24) Vs (58.59 ± 17.44) hours].
Results: (1) Serum bilirubin in group PA neonates before phototherapy and at 6, 12, 24, 48 or 72 hours after starting phototherapy were (253.29 ±33.99), (234.94 ±31.75), (207.49 ±23.19), (176.48 ±41.57), (141.98 ±56.9), (144.41 ±41.48) µmol/L respectively, while those in group PO were (240.86 ±29.76), (229.13 ±28.64), (206.11 ±33.63), (165.30 ±37.24), (123.83 ±36.13), (132.72 ±41.69) µmol/L respectively. They were all similar between two groups (p>0.05); (2)Phototherapy became to drop bilirubin significantly after 12 hours’ phototherapy with an identical velocity and pattern; (3)Plasma albumin levels in group PA was significantly higher than those in group PO after phototherapy [(37.82 ±4.10) Vs (34.40 ±5.44) g/L at 48 hours, (38.90 ±4.47) Vs (35.75 ±3.57) g/L at 72 hours, after starting phototherapy, p<0.05].
Conclusion: (1)Albumin has no effect on serum bilirubin in jaundiced term babies with phototherapy; (2)Phototherapy of 24～48 hours is appropriate for the majority of jaundiced term babies.](./0682.files/image001.gif)
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