文本框: CORRELATION BETWEEN THE BLOOD LIPID LEVELS VERSUS BLOOD PRESSURE, FATTY LIVER AND THE GENETIC PHENOTYPES OF APOE IN THE GROUP OF CHILDREN SIMPLE OBESITY Dong J H, Li W, Zhao H Y Qi Lu Hospital of Shan Dong University，Jinan, China Objective：To determine the relationship of the degree of obesity and the serum contents of blood lipid with the level of blood pressure(BP) and the incidence of fatty liver in children with simple obesity, and the effect of the determination of genetic phenotype of apoE (apolipoproteinE) on blood lipid level. Methods: We studied 120 cases of simple obesity patient and 80 children of normal, respectively. Venous blood was obtained after a fast of twelve hours. The different methods of analysis were used, including detecting blood lipid with enzymic method and turbidimetry, genetic phenotype of apoE with isoelectrofocusing electrophoresis, BP with electromanometer, and liver with abdominal type-B ultrasonography, respectively. Results: There are higher serum levels of TG(triglyceride), T-ch(total cholesterase), HDL-ch(high density lipoprotein) and ApoA1 in patients with simple obesity; the average serum levels of T-ch, LDL-ch decreased in the phenotype of ApoE 2/3. Body mass index (BMI) and average body fat content (%) exist a positive correlation with TG, T-ch, LDL-ch, HDL-ch. The index above in phenotype of ApoE 4/3 has a positive correlation with the levels of LDL-ch and ApoB. We also observed a positive correlation between the degree of fatty, TG and the incidence of hypertension and fatty liver. Conclusion: The children with simple obesity have the disorders of lipometabolism. Fatty children are prone to hypertension, and the incidence of fatty liver is higher in simple obesity. ApoE genetic polymorphism has an effect on the level of blood lipid and the degree of obesity. Early interventional treatment is of great importance to children with simple obesity for both academic and clinical value. 0692