study of medicinal treatment of refractory
nephrotic syndrome (rns) in children
Dong Shulan
The Affiliated Hospital of
Qingdao University Medical College, Qingdao, China
Objective: To study the therapeutic
effects of single prednisone (pred) treatment and combined treatment in
children with RNS .
Methods: 296 children with RNS were
randomly divided into four groups. Group A (control) only received oral
pred (1.5-2mg/kg/d) at one-day intervals; Group B, C, and D (acting as
treating groups) received a combination of oral pred plus IVIG (400mg/kg/d,
for 3~5 days),oral pred plus polysaccharide sulfate(PSS 1-2mg/kg/d, for
7~10 days) and oral pred plus intravenous cyclophosphamide (CTX 10mg/kg/d,
for 2 days), respectively. The treating groups received the same dose of
pred as group A.
Results: After 3-month treatment,
the remission rate in group B(75%),C (74%),and D(71%) were 18% higher than
that in group A (53%) (p<0.05 or 0.01); but no difference of remission
rate among group B,C and D; side effects were observed in 78% of group A,
13% of group B,14% of group C, and 25% of group D. After 12-month treatment
,the remission rates in group A, B, C, and D were 62%, 76%, 89%, and 91%, respectively
(c2=26.12, P<0.001);
the remission rates in group B, C, and D were 14% higher than that in group
A (P<0.05 or 0.001);and side effects were observed in 58% of group A, 7%
of group B, 12% of group C, and 10% of group D(P<0.05).
Conclusion:
Combined medicinal treatment obviously enhanced
the therapeutic effect on children with RNS and had high remission rate,
little side effect and short curative duration.