文本框: VACCINATIONS AT AND BEYOND 2000 Al-Hady E.M1 Directorate of Health Affairs, Jeddah, Saudi Arabia Professor of Pediatrics, Zagazig University, Egypt New Pediatric combination vaccines are in the way. Combining vaccines are designed to increase vaccine coverage. Some measurements (e.g. safety and antibody concentrations versus priming and immunologic memory) will determine which combination vaccines will be used in the near future. With the recently introduced antigens, over 10 new combination products exist that have been introduced or will be introduced in the next decade. e that contain antigens to protect against six diseases: diphtheria, tetanus, pertussis, Hemophilus influenzae type b (Hib), poliomyelitis (IPV) and hepatitis B (DtaP – IPV – Hib – HB). Additional valences will be added after the turn of the century. Protein conjugation of polysaccharides will allow to universal use of Pneumoccoccal (pnc), meningococcal vaccines (A/B/C), besides respiratory syncytial virus vaccine RSV (9 combination vaccines) from the age of 2 months. An intranasal influenza vaccine is likely to be used in children on a wide scale to prevent epidemics. The orally administered rota-virus vaccine will be applied in industrialzed countries, and one hopes eventually in developing countries. Some update knowledge on polio will be discussed as regards disease eradication and choice of vaccine. Many important vaccine targets remain for the new century: R.S.V. and otitis for infants, cytomegalovirus, Ebestien Barr Virus (EBV) and HIV for adolescents, Helicobacter pylori and human papilloma virus for adults, and malaria and dengue for all ages in certain areas. Current advances in technology should permit the realization of those vaccines. Viz. Newer strategies are available now, permitting approaches to these vaccines development that were impossible before, like D.N.A. vaccines. Its idea will be discussed briefly. 0706