文本框: CHANGES AND CLINICAL SIGNIFICANCE OF PLASMA CARBON MONOXIDE AND NITRIC OXIDE LEVELS IN PERINATAL ASPHYXIATED NEONATES Shi Y, Pan F, Li HQ, Pan J, Qin SW, Jiang DB, Zhao JN, Shen JG Department of Pediatrics, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China Objectives: To study the changes of plasma carbon monoxide (CO) and nitric oxide (NO) levels in asphyxiated neonates. Methods: Plasma CO and NO levels of 33 perinatal asphyxiated neonates and 30 healthy newborn infants were measured. Results: The plasma CO and NO levels were significantly increased in the perinatal asphyxiated neonates than those in the normal controls (P<0.05). The plasma CO and NO levels were closely related to the occurrence and the severity of hypoxic-ischemic encephalopahty (HIE). The perinatal asphyxiated patients with HIE had significantly higher CO and NO levels as compared with those without HIE and the normal controls (P<0.05, respectively), and there were no significant diffe-rences in CO and NO levels between the perinatal asphyxiated patients and the normal controls (P>0.05). Moreover, in the patients with HIE, the higher CO and NO levels were, the severer of the stage of HIE (P<0.05). Conclusion: The role and the clinical meaning of CO in perinatal asphyxia need further investigating. 0736