文本框: PLASMA CARBON MONOXIDE LEVELS IN PEDIATRIC SEPSIS SYNDROME
Shi Y, Pan F, Li HQ, Zhao JN, Pan J, Shen JG
Department of Pediatrics, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China

Objective: To study the changes of carbon monoxide (CO) and nitric oxide (NO) levels in pediatric patients with sepsis syndrome. 
Methods: A prospective, observational study of 12 patients aged 3 months to 8 years with the sepsis syn-drome were performed. Plasma CO levels were measured at the time of hospital admission and compared with those 30 age-matched control subjects. 
Results: The plasma CO levels were found to be significantly increased in the patients with the sepsis syndrome as compared with those in the control subjects (P<0.05). The septic patients with shock had significantly higher plasma CO levels than those without shock (P<0.05). Moreover, the increased plasma CO levels were statistically related to the plasma NO levels (P<0.05). 
Conclusions: The present study suggested that CO, in addition to NO, might play an important role in the pathogenesis of the sepsis syndrome. 


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