ORAL CARE OF HARBOR TREATMENT WITH
METHOTREXATE (MTX) IN PEDIATRIC ACUTE LYMPHOCYTIC LEUKEMIA
Qiao
S-J, Wu L-J, Zhang W-J, Li S-L, Ma J
Harbin Institute of Hematology &
Oncology, Harbin, China
Objective: To compare routine (empiric) oral care, leucovorin calcium solution plus
routine oral care was for preventing oral mucosa injury during MTX
treatment.
Methods: There were two groups; each group for 30 patients; and aged
from 2¡ª14 years. Routine method was for Group 1,there were 13 males and 17
females. Chlorhexidine solution (1:2000) was available to wash and gargle
mouth after getting up, meals and before sleep. Special method for Group 2,
there were 14 males and 16 females; routine method plus 0.6% of leucovorin calcium was used for
washing and gargling mouth.
Results: Group 1, there were 4 oral mucosa injury patients (13%) in the
30 patients. Group 2, there was only one oral mucosa injury patient in the
30 patients. There was a significant difference between the two groups (P<
0.01).
Conclusion: When MTX was used to treat pediatric acute lymphocytic
leukemia, oral mucosa injury occurred in the most patients. Our observation
results showed that 0.6% of leucovorin calcium could prevent oral mucosa
injury and had better effect than routine care method.