文本框: BONE MINERAL DENSITY IN CHILDREN WITH ASTHMA RECEIVING LONG-TERM TREATMENT WITH INHALED BUDESONIDE Xie QL, Wen ZH, Wang F, Huang Z, Chen YH, Huang XF The People’s Hospital of Guangxi Autonomous Region, Nanning, China Objective: To evaluate the effects of long-term treatment with inhaled budesonide (Pulmicort Turuhaler) on bone mineral density (BMD) in children with asthma. Methods: The design was a randomized, parallel group study with three low dosing regiments of 100, 200, and 300 micrograms of inhaled budesonide per day. Each dose group received budesonide for 8 or 12 months. BMD was examined by dual energy x-ray absorptiometry in 45 children (26 males, 19 females) with asthma at beginning, 6 and 12 months after medication and compared them with healthy subjects. Lung function (FEV1) was measured in the patients simultaneously. Results: Following treatment, there was significant increase in FEV1 in asthmatic children. There was no significant decrease in BMD in the patients group before and after treatment at the hip(neck of femur p＞0.05, trochanter of femur p＞0.05, Ward’s triangle p＞0.05), the lumber area of the spine (L2-4, p＞0.05) and forearm (ultradis, distal p＞0.05 ). Conclusion: Long-term treatment with low dose inhaled budesonide dose was not reduced born mineralization in children with asthma. 0746