THE RESEARCH INTO CHILDREN WITH CHLAMYDIA

Fu WY, Cheng HJ, Lu JR

First Hospital, Jilin University, Changchun, China

 

Objective: Based on the fact that the relatively high incidence of chlamydia trachomatis (CT) and chlamydia pneumonia (CP) ,and it has been becoming the focus of  recent research. We carried out a series of studies on children infected with CT and CP to interpret the actual status of CP infection in Changchun district and to testify the vertical transmission from mother to the child, then to discuss the clinical deteting methods of chlamydia.

Methods:  Three groups were investigated by the prospective method from 1993 to 1997: CT isolation from NPS of 49 children with pneumonia by HeLa -229 cell, CT genomic type was deter- mined from 106 mothers and their children. With the method of restriction fragment length polymorphism, CP isolation from NPS of 87 children with pneumonia.

Results: 9 of HeLa-229 cells isolation groups were positive, and its positive rate was 18.4 %, most of them were under the age of 6 months, accompanied CT-IgM elevation; among PCR group 26 of 106 pregnant mothers were CT positive, and their children were 11/106, among correspondence of mothers to children were 10 cases. The same CT genomic type was identified between mothers and their children by PCRRFLP. The vertical transmission rate was 38.5%. The genomic type were E of 5, D of 2, F of 2, J of 1 respectively. 11 of Hep-2 culture group were positive, and its positive rate was 12.6%, of 10 positive cases had elevated CP-IgG/IgM.

Conclusion: Chlamydia is one of the most pathogens of children with respiratory infection in Changchun district, and there is vertical transmission from mothers to children, so we should pay attention to the clinical, diagnostic and treatment research of chlamydia infection.

 
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