文本框: THE NEONATE ASPHYXIA IS RELATED TO CEREBROID MICROCIRCULATION AND FREE RADICAL Liu X-M, Jin X, Diao S-H Heilongjiang Provincial Hospital, Harbin, China Objective: In order to clarify the relationship to cerebroid microcirculation and free radical about the neonate asphyxia, and open up the new way and provide the new theory for diagnosis or treatment of the cerebroid injury by the asphyxia.It is of great importance to decrease the neonatal mortality and the handicapped rate. Therefore, it will enhance the quality of population. Methods: The Wistar rat's left common carotid artery were ligated after it was born in seven days. Then the Wistar rats had breath of mixed air in 8% concentration oxygen and 92% concentration nitrogen for two hours. This process will result in cerebroid injury of the Wistar rats by the scarcity of the oxygen and the blood. We call it animal model. These rats were divided into three groups:the control group,the asphyxia group and the treatment group by cerebrolysin. After asphyxia of 6h, 24h, 72h and 120h, we died Wistar rats by encephalotomy and took out the brain tissue. Then we made tissue into section. The sections were stained by hematoxylin-eosin or plumbiferous oil and observed from an electron-microscope and a photomicroscope. By the means of the radioimmunodetection biochemical inspection,we compared the morphology and construction of the brain tissue of the three groups.We measured out the brain moisture,the tumor necrosis factor(TNF-a),the interleukin-1 (IL-1), the thromboxane (TBX2), the6-Keto-Prostaglandin F1a (6-Keto-PGF1a), malonaldehyde (MDA), he superoxide dismutase (SOD), the glutathione peroxidase (GSH-PX). All the data were analysed by Minitab software. Results: The brain moisture, TNF-a, IL-1, TXB2, MDA, SOD, 6-Keto-PGF-1a in asphyxia group were remarkably increased then control group's. After asphyxia of 24h, it was particularly increased. After the treatment by cerebrolysin, seven factors above were conciderably decreased. With the period prolonged, the degree of decrease was very clear, and then was tending towards normal. However, GSH-PX in asphyxia group was all remarkably decreased after 6h, 24h, 72h and 120h.After 24h asphyxia, it was clearly decreased. After the treatment by cerebrolysin, GSH-PX was increased. With the period prolonged, It was remarkably increased, and then was tending towards normal. Conclusion: The asphyxia makes cerebroid microcirculation and free radical changed. The changes play an important role in scarcity of oxygen and scarcity of blood. Cerebrolysin could recover normal from wet brain and increase the capability of antioxidation, promote the metabolism of the brain cell and recovery of the function.It could protect the brain cell. In the present study, it provides the basis for treating the neonate asphyxia because of scarcity of the oxygen and the blood. 0772