文本框: RESEARCH ON THE CLINICAL VALUE OF GM-CSF IN CEREBROSPINAL FLUID IN INTRACRANIAL INFECTIOUS DISEASES Li Z-F, Luo Y, Liu J-S Linyi People’s Hospital, Liyi City, Shandong, China Objective: To study the value of the differences of GM-CSF levels in normal cerebrospinal fluid and in the cerebrospinal fluids of viral cerebritis and bacterial meningitis so as to confirm diagnosis and guide treatment of these diseases. Methods: GM-CSF levels of different specimens were determined by double-antibody sandwich ELISA. Results: The GM-CSF levels of the 20 cases of the normal group were 26.5+42.49 ng/L, among which 90%<100ng/L, 80%<10 ng/L. The GM-CSF levels of the 34 cases of viral cerebritis were 32.5+40.17ng/L, among which 97.1%<100ng/L, 61.8%<10ng/L. The GM-CSF levels of the 23 cases of bacterial meningitis were 218.9+134.73ng/L, among which 86.96%<100ng/L. There was no significant difference between the normal group and the viral cerebritis group (P>0.05). However, there were significant difference between the normal group and the bacterial group or between the viral cerebritis group and the bacterial group (P<0.001). Bacterial meningitis was determined by GM-CSF>100 ng/L with a specificity of 94.44%, a sensitivity of 86.96%, and an accuracy of 93.51%. Conclusion: GM-CSF plays an important role in the anti-infection non-specific cellular immunity. Bacteria and their production is the primary substance that stimulates and regulates the production of GM-CSF. GM-CSF increases notably in bacterial meningitis and can be taken as an objective index in clinical diagnosis. 0795