IMMUNOLOGIC ABNORMALITIES IN ACUTE Guillain-BARR syndrome PATIENTS OF DIFFERENT CLINICAL PATTERNS

Wu M1, Cai F-C2

1 Chengdu Children's Hospital, Chengdu, Sichuan, China

2 Children's Hospital, Chongqing Medical University, Chongqing, China

 

Objective: To study the impact of immunologic abnormalities on pathogenesis of acute Guillain-Barré syndrome (GBS) patients with acute motor axonal neuropathy (AMAN) and acute inflammatory demyelinating polyneuropathy (AIDP).

Methods: The cytokines, IgG production in the serum and cultured supernatants of peripheral blood mononuclear cells (PBMCs) from 12 AMAN, 9AIDP patients and 16 age-matched healthy controls were measured.

Results: The cytokine levels of interleukin (IL)-2 in the serum and IL-2, IL-6, tumor necrosis factor (TNF)-α, IgG in the PBMC supernatants of AMAN and AIDP group and TNF-αin the serum of AMAN group were statistically higher than those in controls (q=3.0~7.5, p<0.05 or 0.01).  Furthermore, the level of TNF-αin the PBMC supernatants of AMAN was obviously higher compared with the AIDP group (q=3.78,p<0.05). Serum IgG, IgA, IgM and IgG subclasses were elevated in 13 patients.

Conclusions: There were a T cell immunity abnormality and a polyclonal  B cell activation in AMAN and AIDP patients. The TNF-αmay play an important role in the pathogenesis of AMAN patients.

 

 
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