A STUDY ON HUMAN
PARVOVIRUS B19 INFECTION IN PEOPLE IN ZHAOQING
Cai Dingbang, Chen Xiang,
Guo Liang, Wen Zhong, Lu Xing, Mo Weixiong, Yan Zhixian
The First People’s
Hospital, Zhaoqing, China
Objective：To study the prevalence of human parvovirus B19 infection in various people in
Zhaoqing. Method：Human parvovirus B19 DNA was
detected with nested polymerase chain reaction (PCR) in various people. Result：⑴ The positive detective rates were 8.72% in 1662 cases of healthy people, 10.71% in
newborns, 10.27% in pregnant women and 5.08% in normal adults,
respectively. The new borns and pregnant women had higher positive rate
than adults (P＜0.01), but no significant difference existed between
infants and adults and no sex difference was found. ⑵ Among 101 pairs of newborns(including 2 pairs of
twins) and maternal women, the positive detective rates were 19.42% in
newborns and 12.87% in maternal women(there was no significant difference
between them), co-positive rates were 2.97%. The newborns and maternal women
had higher positive rate than normal people (P＜0.01). 2 cases of hydrocephalus and edema
occurred in 20 cases of positive newborns. ⑶ The positive detective
rate was 5.08% in 374 cases of blood donors, including 6.45% in 93 cases of
A type, 3.45% in 58 cases of B type, 13.64% in 44 cases of AB type and
2.79% in 179 cases of O type. ⑷ The positive
detective rate were 28.54% in 522 cases of hospitalized newborns and
children, including 46.21% in 132 newborns and 22.56% in 390 children，significantly higher than those in normal newborns
and children (P＜0.01＝. ⑸ The positive detective
rate was 33.33% in 84 cases of congenital cleft lip and cleft palate,
significantly higher than that in hospitalized and normal children (P＜0.001＝. ⑹ The positive detective rate was 19.1% in 63
cases of idiopathic thrombocytopenic purpura (ITP), significantly higher
than that in normal children (P＜0.01＝. ⑺ The positive detective
rate was 34.69% in 49 cases of congenital cerebralpathy, significantly
higher than that in other 102 hospitalized children (P＜0.01＝. ⑻ The positive detective rate was 51.4% in 72 cases
of congenital heart defect, significantly higher than that in hospitalized
and normal children (P＜0.01＝). Conclusions： ⑴ The positive infection rate of parvovirus B19
in healthy population rages from 5.08% to 10.71%. Owing to lower immunity
and resistance to infection as physiological cause, there are higher
infection rates in newborns and pregnant women. ⑵ The positive infection rate of parvovirus B19,
in blood donors is 5.08%. To prevent the infection of parvovirus B19
the use of positive blood should be prohibited in blood donors. ⑶ The positive infection rate is respectively 46.21%
and 22.56% in hospitalized newborns and children, significantly higher than
that in normal newborns and children. There are very high infection rates
in some congenital diseases as cleft lip and cleft palate, cerebralpathy
and heart defect. In addition, the infection of parvovirus B19
in pregnant women might result in congenital anomaly. The parvovirus B19
infection might also play a role in the pathogenesis of ITP.