文本框: STUDIES ON INTELLIGENCE AND BRAIN EVOKED POTENTIALS IN LEAD POISONED CHILDREN
Chen Y! , Li N-X2, Huang Y-L2
Shenzhen Children`Hospital1, Shenzhen, China
Tongji Medical University Union Hospitol2, Wuhan, China

Objective: The relation between low-lead exposure and deficits in neuropsychological development in children had a lot of studies in these years. To probe into the basis of brain electrophysiology of the neuropsychological and behavioral toxicity, the lead poisoned children’s changes of the intelligence and brain evoked potentials were studied in this article.
Methods: According to the blood lead level and questionnaire about personal, social and family, some factors related to intelligence were excluded. The 45 children aged 6 to 12 were divided into two groups: the high lead group (Pb≥10ug/dl) and the low lead group (Pb<10ug/dl). The two groups were measured the Weschsier Intelligence Scales (WISC) , Sensory Evoked Potentials (SEP) and the P300 Event-related Potentials (ERP) separately. It could evaluate entirely lesion extent of intelligence, sensory system and advance mental function in the lead poisoned children.
Results: This article reported that General IQ and Verbal IQ were significantly lower in high lead group than in low lead group. And performance IQ was also lower, but there was no significant statistical difference in two groups. The studies indicated that lead-induced changes in SEP, mainly in N35, P45 and N60, demonstrated the wave losing, the component differentiation lacking or the latency increasing. The studies of ERP in lead poisoned children indicated the amplitude of N200, P300 decreased and the latency of N200, P300 increased.
Conclusion: The WISC was widely used as a standard of IQ. Brain evoked potentials could directly reflect cerebral function: SEP could reflect sensory function and P300 was widely used as an assessment of human advanced mental function. Through these studies, the fundament of neuro-electrophysiology and the evidence for prevention, diagnosis and therapy of neurotoxicity and neuropsychological deficit in lead poisoned children was provided.
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