THE
EXPERIMENTAL STUDY OF ULTRAFILTRATION APPLIED TO LOW FLOW VV-ECMO IN SHEEP
Gan
XZ, Song GW, Huang WX, Zhang Q, Li H, Ma GS,
Sun
LP, Zhang XL
Capital
Institute of Pediatrics, Beijing, China
Objective: To evaluate the efficiency of UF on removing blood urea
Nitrogen (BUN) and the effect of low flow VV-ECMO on eliminating carbon
dioxide and oxygenation in sheep.
Methods: 16 sheep were ventilated after anesthesia with right internal
jugular and femoral venous cannula. In this way the sheep were in apnea for
8min with hypercapnia and randomized to ECMO group and ECMO+UF group. The
ECMO pump rates in two groups were 30ml/kg/min. The BUN and blood gas
analyses of samples from femoral artery, pre-oxygenator and post-oxygenator
were measured at 30,60,90,120,180min during procedures.
Results: The sheep in ECMO and ECMO+UF group were21¡À3and19 ¡À2kg in
weight; The BUN were 28.5¡À5.3and 27.4¡À4.4mg/dL PHPaCO2PaO2 were 7.168¡À0.06
and 7.168¡À0.085; 82.1¡À11.8 and 81¡À11.1mmHg123¡À50 and 130¡À27mmHgrespectively
in pre-therapy. At 180min post-therapy, the BUN of ECMO group was29.5¡À4.3
mg/L, compared with ECMO+UF group 23.7¡À3.7mg/dL , p<0.05; The artery PH
increased to 7.368¡À0.04 and7.342¡À0.078PaCO2 decreased to
47.1¡À6.4and48.9¡À6.7mmHg;PaO2 were 94.8¡À15.6 and 102¡À32.9mmHg respectively,p>0.05.
Lower PCO2 and higher PO2 of both groups were showed in post-oxygenator
than in pre-oxygenator, p<0.05.
Conclusions:
The UF effectively removed BUN of sheep with
low flow VV-ECMO could eliminate carbon dioxide and oxygenate to a great extent.