A CLINICAL TRIAL OF BECOTIDE OMBINED WITH SPECIAL IMMUNO-DESENSITIZATION IN PREVENATING AND TREATING NFANTILE ASTHMA

Huang Y, Zhang R-Y, Shi T-T

Children’s Hospital, Chongqing University of Medical Sciences, Chongqing, China

Objective: To evaluate the clinical efficiency and safety of early and long-term course of Becotide (BCD) combined with special immuno- densensitization (SID) in treating infantile asthma.

Methods: Eighty-two patients with infantile asthma were administered BCD and SID compared with the controls including forty-six patients with infantile asthma without treatment. The total course was at least one year and the average time of the following up was 2.5 years .The level of serum IgE, IgG, IgA, IgM, T lymphocyte subsets and pulmonary function were tested before and after the treatment.

Results: PEF and FEV1 in the patients received the treatment recovered compared with the controls. Serum IgG, IgA, CD₃, CD₈ increased and IgE, CD₄/CD₈ decreased significantly (P<0.01). The total clinical effeciency rate was 91.46% (75/82).

Conclusions: Early and long-time course of BCD and SID are effective on treating and preventing infantile asthma.

0825