CLINICAL
SIGNIFICANCE OF SERUM INTERLEUKIN-1 RECEPTOR ANTAGONIST ANTIBODY IN
CHILDREN WITH ACUTE IDIOPATHIC THROMBOCYTOPENIC PURPURA
Zhang
BR, Li X, Wang Q, Zhu J, Jia WY.
Tianjin
Children¡¯s Hospital, Tianjin, China
Objective: To explore the
level of serum interleukin-1 receptor antagonist (IL-1Ra) antibody and its
relationship with clinical situation and prognosis in children with acute
idiopathic thrombocytopenic purpura (AITP).
Methods: Serum level of IL-1Ra antibody was measured by ELISA.
Results: Serum level of IL-1Ra antibody in 32 AITP patients was
significantly higher than that in controls (p<0.05), but no significant
difference was demonstrated between the two groups of patients with
hemorrhage of different severity (p>0.05). There was no significant
correlation between the level of IL-1Ra antibody and megakaryocyte count in
marrow (p>0.05). The level of IL-1Ra antibody was positively correlated
with PAIgG (p<0.005,r=0.78). The level of IL-1Ra antibody was decreased
in 10 patients after the platelet count became normal.
Conclusion: Whether the level of IL-1Ra antibody can be considered as
prognostic index for patients with ITP should be further studied.