THE STUDY ON THE SERUM
GRANULOCYTE COLONY STIMULATING FACTOR LEVELS AND IT'S CLINICAL SIGNIFICANCE
IN CHILDREN WITH PNEUMONIA
Xia Guangming, Chen
Saying, Lai Hong, et al
Department of
Pediatrics, China-Japan Friendship Hospital, Beijing China
Objective: To explore
the serum granulocyte colony stimulating factor (G-CSF) levels and it's
clinical significance in children with acute pneumonia.
Methods: The G-CSF
levels in serum of 61 children suffered from acute pneumonia were measured
by enzyme linked immunosorbent assay (ELISA) for G-CSF. The direct
relationship between G-CSF levels and white blood cell count, absolute
granulocyte numbers in blood, temperature of patients, C-reactive protein
(CRP) were observed and the change of G-CSF levels after treated were also
studied.
Results: (1) 62.29%
of samples detected showed positive reaction for G-CSF. (2) The G-CSF
levels were higher in the groups of fever than the groups of no fever. (3)
89.41% of white blood counts in cases examined were normal, 73.68% of
granulocytes were increased. 94.44% of CRP tests showed negative reaction
in the cases of positive reaction for G-CSF. (4) The G-CSF reactions become
negative immediately after the infection under controlled.
Conclusions: The
detection of the levels of G-CSF in serum of children with acute pneumonia
may apply a quick sensitive and faithful mark for the cause of the disease,
having an important clinical significance.