文本框: CARDIOVASCULAR RISK FACTORS IN 12-YEAR-OLD CHILDREN BORN WITH MATERNAL PRE-ECLAMPSIA Voutilainen R, Tenhola S, Rahiala E, Martikainen A Department of Pediatrics, Kuopio University and University Hospital, Kuopio, Finland Women with prior pre-eclamptic pregnancies have been found to be in increased risk for metabolic syndrome and cardiovascular diseases. Maternal pre-eclampsia has also been associated with elevated blood pressure in offspring already in childhood. Objective: The aim of our study was to determine whether the matabolic changes, such as dyslipidemia, hypertension and insulin resistance, are found in 12-year-old children of pre-eclamptic mothers (PRE children). Methods: We studied the blood pressures and the concentrations of serum total and HDL cholesterol and triglycerides, fasting insulin and blood glucose in 60 PRE children and their age- and sex-matched control subjects of normotensive mothers (non-PRE children) at the age of 12 years. Results: The PRE children had significantly higher mean systolic (116.4 vs. 113.2 mmHg, p=0.021) and diastolic blood pressures (73.9 vs. 70.3 mmHg, p=0.022) than the non-PRE children when adjusted by current weight and height. The mean concentrations of serum total (4.54 vs. 4.50 mmol/L, p=0.618), LDL (2.82 vs. 2.75 mmol/L, p=0.342), and HDL cholesterol (1.31 vs. 1.36 mmol/L, p=0.468), serum triglycerides (0.90 vs. 0.86 mmol/L, p=0.617), fasting insulin (10.2 vs. 9.7 mU/L, p=0.505) and blood glucose (4.3 vs. 4.4 mmol/L, p=0.371) did not differ between the study and the control group. Conclusion: Maternal pre-eclampsia may have an influence on an offspring's blood pressure already at 12 years age.

0862