ANTIOXIDANT LEVELS BEFORE AND AFTER CARDIAC CATHETERIZATION IN THE CONGENITAL HEART DISEASE PATIENTS

Parlar A, Güven H, Levent E, Delen Y, Özyürek R

Ege University, Medical Faculty, Department of Pediatric Cardiology and Biochemistry, Izmir, Turkey

The aim of this study is to evaluate the antioxidant levels before and after cardiac catheterization in the children with congenital heart disease.

In the pediatric cardiology department, total 20 patients who had cardiac catheterization were evaluated. Superoxide dismutase (SOD) and Catalase (CAT) levels were taken from the patients before and after the cardiac catheterization. The patients have no pathologic condition and infection. The patient group consists of 16 patients with Ventricular septal defect and 4 patients with Tetralogy of Fallot. The ages of VSD patients were 69.2±52.3 months and ages of TOF patients were 78.5±53.8 months. The group consists of 12 male and 8 female patients. SOD levels in the VSD patients before and after catheterization were found as 1480±593 Ug/Hb and 1063±968 Ug/Hb consequently (p<0.05). In the same group CAT levels before and after cardiac catheterization were found as 2787±693 Ug/Hb and 2239±887 Ug/Hb. SOD and CAT levels in the TOF patients before and after cardiac catheterization were found as 884±536 Ug/Hb, 909±548 Ug/Hb and 3375±956 Ug/Hb, 3507±968 Ug/Hb consequently. The difference between the levels was statistically insignificant. Although the SOD levels in the TOF patients show a decrease after cardiac catheterization, there was no statistically significantly.

As a conclusion, especially in TOF patients SOD levels are decreasing after the cardiac catheterization. This situation can show that syanotic patients have more oxidative stress during cardiac catheterization.

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